In Leonardo da Vinci's studio, bursting with genius imagination, towering commissions and needling patrons, as well as discontented muses, friends and rivals, sits the painting of the Mona Lisa. For five hundred tumultuous years, amid a whirlwind of power, money, intrigue, the portrait of Lisa del Giocondo is sought after and stolen. Over the centuries, few could hear her voice, but now she is ready to tell her own story, in her own words - a tale of rivalry, murder and heartbreak. Weaving through the years, she takes us from the dazzling world of Florentine studios to the French courts at Fontainebleau and Versailles, and into the Twentieth Century.